Therapy of tacrolimus combined with corticosteroids in idiopathic membranous nephropathy
نویسندگان
چکیده
منابع مشابه
Therapy of tacrolimus combined with corticosteroids in idiopathic membranous nephropathy
We evaluated the efficacy and safety of tacrolimus (TAC) combined with corticosteroids in treating patients with idiopathic membranous nephropathy (IMN). One hundred seventy-seven biopsy-proven IMN patients were recruited in this retrospective clinical study. Sixty patients received TAC (target blood concentration of 4-8 ng/mL) and 117 patients received daily cyclophosphamide (CYC, 100 mg) comb...
متن کاملComparison of efficacy and safety between tacrolimus and cyclosporine combined with corticosteroids in patients with idiopathic membranous nephropathy: a randomized controlled trial
Objectives: Immunosuppressive therapy plays an important role in patients with idiopathic membranous nephropathy (IMN). Evidence regarding the optimal kind of calcineurin inhibitors (CNIs) in treatment of IMN remains unclear. The objective of this study was to examine whether tacrolimus (TAC) is more effective and safe than cyclosporine (CsA) in treating IMN patients. Methods: We conducted a pr...
متن کاملPredictors of response and relapse in patients with idiopathic membranous nephropathy treated with tacrolimus.
BACKGROUND Although tacrolimus is recommended by KDIGO Clinical Practice Guideline for Glomerulonephritis for the treatment of idiopathic membranous nephropathy (MN), little is known about factors that influence response and relapse of the disease after tacrolimus therapy. METHODS Multicentre study that collected 122 MN patients with nephrotic syndrome and stable renal function treated with t...
متن کاملCorticosteroids, cyclophosphamide, and chlorambucil therapy of membranous nephropathy.
Corticosteroids and cytotoxic agents have been studied widely in membranous nephropathy (MN). However, controlled studies with corticosteroids have not shown a clear benefit of these agents on the outcome of the disease. Some controlled trials reported that cytotoxic agents can reduce proteinuria significantly, but it was difficult to assess the efficacy of these drugs in protecting renal funct...
متن کاملcomparison of the efficacy of tacrolimus versus cyclosporine in the treatment of idiopathic membranous nephropathy
conclusions cyclosporine and tacrolimus reduce proteinuria and serum creatinine after 6 months. nonetheless, tacrolimus reduces urea and cyclosporine increases it. however, since the prevalence of the side effects of both drugs is similar, tacrolimus has better results in the treatment of imn patients compared with cyclosporine. background immunosuppressive drugs have received the most attentio...
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ژورنال
عنوان ژورنال: Brazilian Journal of Medical and Biological Research
سال: 2017
ISSN: 1414-431X,0100-879X
DOI: 10.1590/1414-431x20175976